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Accueil du site > Équipes de recherche > Chimie Organique et Médicinale > Peptoid > Thèmes de recherche > Multivalent peptoid architectures

Multivalent peptoid architectures

Multivalent glycopeptoids (linear and cyclic) are being currently developed to obtain high-affinity ligands for lectin receptors.


Solution-phase synthesis of linear and cyclic β- and α,β-peptoids was coupled to photo-induced thiol–ene coupling (TEC) reactions to readily access multivalent thioglycoclusters. A tetrameric cyclic β-peptoid scaffold displaying 1-thio-β-D-galactose or 1-thio-α-D-mannose has revealed efficient binding potency for bacterial lectins LecA and BC2L-A.


Multivalent thioglycopeptoids via photoclick chemistry : potent affinities towards LecA and BC2L-A lectins
Caumes C., Gillon E., Legeret B., Taillefumier C., Imberty A., Faure S. Chem. Commun. 2015, 51, 12301-12304.

From Glycopeptides to Glycopeptoids.
Szekely T., Roy O., Faure S., Taillefumier C. Eur. J. Org. Chem. 2014, 5641–5657.

Selectivity among Two Lectins : Probing the Effect of Topology, Multivalency and Flexibility of "Clicked" Multivalent Glycoclusters.
Cecioni S., Faure S., Darbost U., Bonnamour I., Parrot-Lopez H., Roy O., Taillefumier C., Wimmerova M., Praly J.P., Imberty A., Vidal S. Chem. Eur. J. 2011, 17, 2146-2159.

Click glycoconjugation of per-azido- and alkynyl-functionalized β-peptides built from aspartic acid.
Barra M., Roy O., Traikia M., Taillefumier C. Org. Biomol. Chem. 2010, 8, 2941-2955.