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Accueil du site > Équipes de recherche > Chimie Organique et Médicinale > Inhibiteurs d’enzymes et de récepteurs > Publications récentes

Publications récentes

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2016
- W. Zeinyeh, Y.J. Esvan, L. Nauton, N. Loaëc, L. Meijer, V. Théry, F. Anizon, F. Giraud, P. Moreau. Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives. Bioorganic & Medicinal Chemistry Letters 2016, 26, 4327-4329.

- Y.J. Esvan, F. Giraud, E. Pereira, V. Suchaud, L. Nauton, V. Théry, L.G. Dezhenkova, D.N. Kaluzhny, V.N. Mazov, A.A. Shtil, F. Anizon, P. Moreau. Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c. Bioorganic & Medicinal Chemistry 2016, 24, 3116-3124.

- P. Moreau, F. Anizon, F. Giraud, Y.J. Esvan. Heteroaromatic Pim kinase inhibitors containing a pyrazole moiety. Recent Patents on Anti-Cancer Drug Discovery 2016, 11, 309-321.

- Y.J. Esvan, W. Zeinyeh, T. Boibessot, L. Nauton, V. Théry, S. Knapp, A. Chaikuad, N. Loaëc, L. Meijer, F. Anizon, F. Giraud, P. Moreau. Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors : design, synthesis, inhibitory potency and X-ray co-crystal structure. European Journal of Medicinal Chemistry 2016, 118, 170-177.

2015
- F. Giraud, M. Bourhis, E. Ebrahimi, L. Herfindal, R.R. Choudhury, R. Bjørnstad, S.O. Døskeland, F. Anizon, P. Moreau. Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward Acute Myeloid Leukemia cells. Bioorganic and Medicinal Chemistry 2015, 23, 7313-7323.

- N.M. Santio, S.K. Eerola, I. Paatero, J. Yli-Kauhaluoma, F. Anizon, P. Moreau, J. Tuomela, P. Härkönen, P.J. Koskinen. Pim kinases promote migration and metastatic growth of prostate cancer xenografts. PLoS One 2015, 10, e0130340.

2014
- F. Giraud, F. Anizon, P. Moreau. Advances in the synthesis and kinase inhibitory potencies of non-fused indazole derivatives. Targets in Heterocyclic Systems : Chemistry and Properties. O.A. Attanasi, R. Noto, D. Spinelli, Eds. Italian Society of Chemistry, 2014, 18, 1-28.

- V. Suchaud, L. Gavara, F. Giraud, L. Nauton, V. Théry, F. Anizon, P. Moreau. Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition. Bioorganic and Medicinal Chemistry 2014, 22, 4704–4710.

- F. Giraud, M. Bourhis, L. Nauton, V. Théry, L. Herfindal, S.O. Døskeland, F. Anizon, P. Moreau. New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes : synthesis and biological activities. Bioorganic Chemistry, 2014, 57, 108–115.

- P. Moreau, L.G. Dezhenkova, F. Anizon, L. Nauton, V. Théry, S. Liang, D.N. Kaluzhny, A.A. Shtil. New Inhibitor of Pim-1/3 Protein Kinases Sensitizes Human Colon Carcinoma Cells to Doxorubicin. Anti-Cancer Agents in Medicinal Chemistry 2014, 14, 1228–1236.

- E. Pereira, A. Youssef, M. El-Ghozzi, D. Avignant, J. Bain, M. Prudhomme, F. Anizon, P. Moreau. Synthesis of dipyrrolo[3,4-a:3,4-c]carbazoles : new kinase inhibitors. Tetrahedron Letters 2014, 55, 834–837.

2013
- V. Suchaud, L. Gavara, E. Saugues, L. Nauton, V. Théry, F. Anizon, P. Moreau. Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors. Bioorg. Med. Chem. 2013, 21, 4102-4111.

- L. Gavara, V. Suchaud, L. Nauton, V. Théry, F. Anizon, P. Moreau. Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors. Bioorg. Med. Chem. Lett. 2013, 23, 2298-2301.

- G. Sarek, L. Ma, J. Enbäck, A. Järviluoma, P. Moreau, J. Haas, A. Gessain, P.J. Koskinen, P. Laakkonen, P.M. Ojala. Kaposi’s sarcoma herpes virus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas. Oncogene 2013, 32, 1091-1098.